His first significant canvas is "A Lover of Absinthe" (1858). Among the most famous paintings by Mane is "Breakfast on the Grass". Paris salon refused to show it, but he exposes at the Salon rejected in 1863 depicted her dressed men and naked women are too daring for its time. Mane is very offended and bitter by the reaction to his canvas. In the art of artists, it is then accepted, in order to perfect the mastery, to copy the canvases of the great artists, each interpreting them in their own way. Velasquez, one of Mane's models, often copies Ticiana's canvases. The group of people presented at the "Breakfast on the Grass" is inspired by the "Country Concert" by Renaissance artist Giorgio.
Another of his famous paintings, whose idea is borrowed from Ticiana's Venus, is "Olympia", again denied by the jury of the Paris Salon. This sail was swept up by the French society, but it became the only picture everyone wanted to see. There are so many crowds gathering around her that they have to put two guards to bring order.